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Treatment of osteoporosis is typically based on the administration of pharmacological agents that reduce fracture risk in patients with prevalent fragility fractures. However, there are limitations to this approach and osteoporosis therapy is seldom adopted on this basis. The publication of the results of the Women’s Health Initiative trial provided a challenge to the efficacy and safety of antiresorptive agents and highlighted the unmet need to enhance antifracture efficacy and avoid the adverse events associated with chronic therapy with antiresorptive agents. We have observed, following the publication of the results of the Women’s Health Initiative study, that there is increasing interest in the development of new treatment options for osteoporosis. And because of the possibility of an interaction between antiresorptive agents and vitamin D, interest in the use of novel therapies such as teriparatide and parathyroid hormone has increased. An injectable formulation of parathyroid hormone has been developed that not only enhances antifracture efficacy but also demonstrates a greater safety profile in a rodent model of osteoporosis. The possibility of using a combination of a teriparatide-like agent and a receptor activator of the nuclear factor kappa B ligand (RANKL)-analogue would, in theory, yield a greater antifracture effect than either component alone. Although injectable products are not in common use, the future may see novel injectable formulations of existing drugs used for the treatment of osteoporosis.Dietary fibre concentrations and composition of commonly consumed oilseed meals in relation to gastrointestinal transit times in humans.
This study was undertaken to establish concentrations of dietary fibre (DF) and composition of five commonly consumed oilseed meals in relation to gastrointestinal (GI) transit times. Fibre concentrations were quantified by 10 h chloritetracycline (CTC) extraction and composition by the difference method. GI transit times were estimated by transit time index (TTI) calculated from the cumulative, cumulative percent breakdown and cumulative number of capsule markers. Concentrations of dietary fibre varied widely among oilseed meals (33-40% DF, DF/starch ratio

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